|
Tumor Cell Invasion
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Collectively, we conclude that TOPK positively regulates TBX3 in TGF-β1/Smad signaling pathway, thereby enhancing EMT and invasion of breast cancer cells, implying a mechanistic role of TOPK in TGF-β1/Smad signaling.
|
31757421 |
2020 |
|
Malignant neoplasm of breast
|
0.060 |
Biomarker
|
disease |
BEFREE |
TOPK promotes epithelial-mesenchymal transition and invasion of breast cancer cells through upregulation of TBX3 in TGF-β1/Smad signaling.
|
31757421 |
2020 |
|
Breast Carcinoma
|
0.060 |
Biomarker
|
disease |
BEFREE |
TOPK promotes epithelial-mesenchymal transition and invasion of breast cancer cells through upregulation of TBX3 in TGF-β1/Smad signaling.
|
31757421 |
2020 |
|
Non-Small Cell Lung Carcinoma
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
We highlight the conventional mechanisms of drug resistance elicited by the complex heterogeneous microenvironment of NSCLC during targeted therapy, including mutations in epidermal growth factor receptor (EGFR), anaplastic lymphoma kinase (ALK), the receptor tyrosine kinase ROS proto-oncogene 1 (ROS1), and the serine/threonine-protein kinase BRAF (v-Raf murine sarcoma viral oncogene homolog B).
|
31715289 |
2020 |
|
Malignant Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The mitotic kinase T-LAK cell-originated protein kinase/PDZ-binding kinase (TOPK/PBK) is associated with proliferation of tumor cells, maintenance of cancer stem cells, and poor patient prognosis in many cancers.
|
31714026 |
2020 |
|
Primary malignant neoplasm
|
0.080 |
Biomarker
|
group |
BEFREE |
The mitotic kinase T-LAK cell-originated protein kinase/PDZ-binding kinase (TOPK/PBK) is associated with proliferation of tumor cells, maintenance of cancer stem cells, and poor patient prognosis in many cancers.
|
31714026 |
2020 |
|
Malignant tumor of colon
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
T-LAK cell-originated protein kinase (TOPK) belongs to serine/threonine protein kinase and is highly expressed in several cancer cells and tissues, such as colon cancer, lung cancer, esophagus cancer, and so on.
|
31708778 |
2019 |
|
Malignant neoplasm of lung
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
T-LAK cell-originated protein kinase (TOPK) belongs to serine/threonine protein kinase and is highly expressed in several cancer cells and tissues, such as colon cancer, lung cancer, esophagus cancer, and so on.
|
31708778 |
2019 |
|
Carcinoma of lung
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
T-LAK cell-originated protein kinase (TOPK) belongs to serine/threonine protein kinase and is highly expressed in several cancer cells and tissues, such as colon cancer, lung cancer, esophagus cancer, and so on.
|
31708778 |
2019 |
|
Colon Carcinoma
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
T-LAK cell-originated protein kinase (TOPK) belongs to serine/threonine protein kinase and is highly expressed in several cancer cells and tissues, such as colon cancer, lung cancer, esophagus cancer, and so on.
|
31708778 |
2019 |
|
Primary malignant neoplasm of lung
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
T-LAK cell-originated protein kinase (TOPK) belongs to serine/threonine protein kinase and is highly expressed in several cancer cells and tissues, such as colon cancer, lung cancer, esophagus cancer, and so on.
|
31708778 |
2019 |
|
Malignant neoplasm of esophagus
|
0.010 |
Biomarker
|
disease |
BEFREE |
To sum up, eupafolin as an TOPK inhibitor can suppress growth of esophagus cancer <i>in vitro</i> and <i>in vivo</i>.
|
31708778 |
2019 |
|
Glioblastoma Multiforme
|
0.050 |
AlteredExpression
|
disease |
BEFREE |
According to the further analysis results of hub genes, we found that the PDZ-binding kinase (PBK) gene had a high expression and significantly worse survival in GBM contrasted to brain normal samples (P < 0.05).
|
31617063 |
2020 |
|
Glioblastoma
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
According to the further analysis results of hub genes, we found that the PDZ-binding kinase (PBK) gene had a high expression and significantly worse survival in GBM contrasted to brain normal samples (P < 0.05).
|
31617063 |
2020 |
|
Adult Glioblastoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
PBK as a Potential Biomarker Associated with Prognosis of Glioblastoma.
|
31617063 |
2020 |
|
Childhood Glioblastoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
PBK as a Potential Biomarker Associated with Prognosis of Glioblastoma.
|
31617063 |
2020 |
|
Non-Small Cell Lung Carcinoma
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
We found that COX2 and TOPK were highly expressed in EGFR-activating mutated NSCLC and the progression-free survival (PFS) of triple-positive (COX2, MET, and TOPK) patients was shorter than that of triple-negative patients.
|
31611604 |
2019 |
|
Nausea and vomiting
|
0.010 |
GeneticVariation
|
phenotype |
BEFREE |
The participants in the PBK group had fewer intraluminal bubbles (0.9% vs 81.3%, P < 0.001) and reported a lower incidence of nausea and vomiting, with better acceptance, taste, and willingness to repeat the regimen than those in the OSS group (all P < 0.05).
|
31396995 |
2020 |
|
Glioma
|
0.060 |
Biomarker
|
disease |
BEFREE |
TOPK inhibits autophagy by phosphorylating ULK1 and promotes glioma resistance to TMZ.
|
31378785 |
2019 |
|
Carcinogenesis
|
0.080 |
Biomarker
|
phenotype |
BEFREE |
Together these studies elucidate the mechanism of PBK in ACC tumorigenesis and establish the potential therapeutic potential of HITOPK032 in patients.
|
31325906 |
2019 |
|
Agenesis of corpus callosum
|
0.010 |
Biomarker
|
disease |
BEFREE |
We show that PBK is regulated by FOXM1 and targeting PBK via shRNA decreased cell proliferation, clonogenicity, and anchorage independent growth in ACC cell lines.
|
31325906 |
2019 |
|
Aplasia Cutis Congenita
|
0.010 |
Biomarker
|
disease |
BEFREE |
We show that PBK is regulated by FOXM1 and targeting PBK via shRNA decreased cell proliferation, clonogenicity, and anchorage independent growth in ACC cell lines.
|
31325906 |
2019 |
|
Tuberculosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
3 compounds out of 5 most active STPK inhibitors have a prominent minimal inhibitory concentration on M. tuberculosis H37Rv of 1 μg/ml.
|
31176094 |
2019 |
|
Renal Insufficiency
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
We observe a positive correlation between miR-103a-3p levels and AngII-induced renal dysfunction. miR-103a-3p suppresses expression of the sucrose non-fermentable-related serine/threonine-protein kinase SNRK in glomerular endothelial cells, and glomeruli of HN patients and AngII-infused mice show reduced endothelial expression of SNRK.
|
31086184 |
2019 |
|
Neoplasm Metastasis
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
In this current study, VCP979, which is a novel p38 MAPK inhibitor with safety and efficacy in inhibiting the activity of serine threonine protein kinase, effectively suppressed orthotopic pancreatic cancer growth and metastasis.
|
31072439 |
2019 |